@ahmad.ruyat12:

Ahmad Ru'yat
Ahmad Ru'yat
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Monday 29 September 2025 18:20:33 GMT
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Your Immune System Doesn’t Recognise Your Eyes #privilege. Immune privilege refers to the phenomenon where certain parts of the body are able to tolerate the introduction of antigens without eliciting an inflammatory immune response. The eyes are a prime example of an immune-privileged site. This unique status helps protect delicate ocular tissues from the potentially damaging effects of inflammation, which could compromise vision. Here’s a detailed description of immune privilege in the eyes and why they do not typically recognize antigens the way other parts of the body do: Immune Privilege in the Eyes Structural Barriers: The eyes are protected by physical barriers such as the blood-retinal barrier and the blood-aqueous barrier. These barriers restrict the movement of immune cells and large molecules from the bloodstream into ocular tissues, limiting exposure to antigens and immune responses within the eye. Anti-Inflammatory Environment: The eye produces various immunosuppressive molecules, such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which create an anti-inflammatory environment. These molecules inhibit the activation and function of immune cells that do manage to infiltrate ocular tissues. Lack of Lymphatic Drainage: Unlike other tissues, the eyes lack conventional lymphatic drainage. This absence reduces the transport of antigens to regional lymph nodes, where they would typically be recognized and responded to by the immune system. Expression of Fas Ligand (FasL): Ocular tissues express Fas ligand, a protein that induces apoptosis (cell death) in Fas-expressing immune cells that enter the eye. This mechanism helps to eliminate potentially damaging immune cells and prevent an inflammatory response. #eyes #immunesystem
Your Immune System Doesn’t Recognise Your Eyes #privilege. Immune privilege refers to the phenomenon where certain parts of the body are able to tolerate the introduction of antigens without eliciting an inflammatory immune response. The eyes are a prime example of an immune-privileged site. This unique status helps protect delicate ocular tissues from the potentially damaging effects of inflammation, which could compromise vision. Here’s a detailed description of immune privilege in the eyes and why they do not typically recognize antigens the way other parts of the body do: Immune Privilege in the Eyes Structural Barriers: The eyes are protected by physical barriers such as the blood-retinal barrier and the blood-aqueous barrier. These barriers restrict the movement of immune cells and large molecules from the bloodstream into ocular tissues, limiting exposure to antigens and immune responses within the eye. Anti-Inflammatory Environment: The eye produces various immunosuppressive molecules, such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which create an anti-inflammatory environment. These molecules inhibit the activation and function of immune cells that do manage to infiltrate ocular tissues. Lack of Lymphatic Drainage: Unlike other tissues, the eyes lack conventional lymphatic drainage. This absence reduces the transport of antigens to regional lymph nodes, where they would typically be recognized and responded to by the immune system. Expression of Fas Ligand (FasL): Ocular tissues express Fas ligand, a protein that induces apoptosis (cell death) in Fas-expressing immune cells that enter the eye. This mechanism helps to eliminate potentially damaging immune cells and prevent an inflammatory response. #eyes #immunesystem

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