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@_itannn15:

yeyennnnn
yeyennnnn
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Region: ID
Tuesday 07 January 2025 15:24:31 GMT
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Comments

mrcchllaprwii_
mrchllaprwii. :
giliran udh dapet yang baik, malah aku yang jahat☹️
2025-01-10 03:59:37
562
enjl161
ajell🌀 :
sorry darling i'm too selfish☹️
2025-01-27 14:53:35
14
echaaakeyah26_06
eca.. :
kasian cowokuu☹️
2025-01-09 14:58:02
30
astagaantann
ntannnnn :
Forgive me☹️
2025-01-28 06:48:47
0
yunikaajaa
yunik4 :
maafinn aku yaa☹️☹️
2025-01-09 08:18:14
65
dwimatchaaaa
dwi💢 :
BUSETT PADA NGETAG COWONYAA🗿
2025-01-08 15:07:23
45
aisolll765
aisahhh :
-egoku terlalu tinggi sehingga salahku pun kamu yang perlu meminta maap kepadaku.
2025-09-23 10:45:02
2
rfhnazrsh
rvazrshaa ☁ :
maaf yaa ..
2025-02-14 14:06:37
0
xyraa4566
nnauuuuuu :
:cerita kita usai karena ke egoisan ku
2025-08-02 07:14:02
1
syalwaajadehh
syalwaajadehh :
kebalik ga si shrusnya mlh gw yg minta maap
2025-09-18 11:12:29
0
disnndry
diss :
ego aku tnggi tp ak ttp mnta maaf ke kmu klo ak ga mnta maaf hub kta akn cpt berakhir,,,🥺
2025-01-09 16:10:50
7
euissmarlinaa15
Issukaayyapping💤 :
@eca..:kasian cowokuu☹️
2025-09-03 08:44:00
1
rhsylln
aayyell :
@uwongg:ego ku memang tinggi, tpi aku akan nurunin ego aku klo itu slah aku
2025-01-28 07:09:55
0
rnblqiss_
balqis_ :
setelah kamu minta maaf sikap kamu berubah, apa kamu masi kecewa sama akuu?☹️☹️☹️☹️
2025-01-28 04:15:46
3
taciaaaa03
୨ৎ୨ৎ :
@cchllaa.:giliran udh dapet yang baik, malah aku yang jahat☹️
2025-02-03 08:39:24
2
pitri_128
stdssk :
maaf
2025-01-09 11:20:45
1
sweet.nanay
n for nayy :
maapp
2025-01-09 09:09:25
0
shaaasukamatchaa
SHAPA :
aku jahat banget ya?
2025-02-06 12:59:07
3
mpaaaaaa13
mpaaaaaa :
bikin vs terbalik kaa plss
2025-01-08 17:08:52
4
nitaaaaa407
. :
mff
2025-01-09 08:07:48
0
unaa_naa26
unaa🔥 :
giliran dapet yang baik banget malah aku yang jahat, yang selalu pengen di mengerti doang tapi gamau ngertiin dia☹️☹️
2025-02-06 11:43:21
4
karisareginaputri08
icha!! :
maaf ya
2025-01-09 02:33:29
3
sintyaa322
tiaaa :
mff
2025-01-09 08:32:22
0
cacaw_1504
🅰️©️🅰️ :
beruntung bat bisa ketemu cowo baik,pengertian,soft spoken, pengertian, tapi kurangnya aku yang ga bisa ngertiin dia wkwk
2025-01-15 12:29:14
1
bilayapping_
bilaaa yapingg🕷️🕸️ :
mau ngetag tapi malu☹️
2025-01-09 09:03:22
5
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🧬 Nobel Prize 2025 in Physiology or Medicine: Part 1 Penelitian oleh Prof. Shimon Sakaguchi yang pada tahun 2025 menerima Nobel Prize in Physiology or Medicine, membuka jalan bagi penemuan Regulatory T cells (Treg). Dalam studi klasiknya (J. Immunol., 1995), limfosit dari tikus BALB/c normal (nu/+) diisolasi dan dibagi menjadi lima kelompok: 1️⃣ Whole lymphocytes (semua sel) 2️⃣ CD25⁻ lymphocytes (semua sel, CD25⁺ dihilangkan) 3️⃣ CD4⁺ CD25⁻ (hanya T helper tanpa CD25) 4️⃣ CD4⁺ CD25⁺ (T helper dengan CD25) 5️⃣ CD8⁺ CD25⁻ (T sitotoksik tanpa CD25) Kelima fraksi ini ditransfer ke tikus BALB/c nu/nu (athymic) yang tidak memiliki timus. Hasil setelah ±3 minggu pengamatan menunjukkan: • Kelompok CD25⁻ dan CD4⁺ CD25⁻ mengalami autoimunitas multipel (gastritis, oophoritis, thyroiditis, glomerulonefritis). • Kelompok whole lymphocytes, CD4⁺ CD25⁺, dan CD8⁺ CD25⁻ tetap sehat. 🧩 Kesimpulan awal: sel CD4⁺ CD25⁺ berperan menekan aktivasi sel T autoreaktif dan menjaga toleransi The work of Shimon Sakaguchi, awarded the 2025 Nobel Prize in Physiology or Medicine, was pivotal in identifying Regulatory T cells (Treg). In his 1995 Journal of Immunology study, Sakaguchi isolated lymphocytes from normal BALB/c (nu/+) mice and divided them into five groups: 1️⃣ Whole lymphocytes – all cells untreated 2️⃣ CD25⁻ lymphocytes – all cells with CD25⁺ removed 3️⃣ CD4⁺CD25⁻ – helper T cells without CD25 4️⃣ CD4⁺CD25⁺ – helper T cells expressing CD25 5️⃣ CD8⁺CD25⁻ – cytotoxic T cells without CD25 Each group was transferred into BALB/c nu/nu (athymic) mice, which lack a thymus. After about 3 weeks, the results were striking: • CD25⁻ and CD4⁺CD25⁻ groups developed multiple autoimmune diseases (gastritis, oophoritis, thyroiditis). • CD4⁺CD25⁺, CD8⁺CD25⁻, and whole lymphocyte groups remained healthy. 🧩 Conclusion: CD4⁺CD25⁺ cells act as regulatory T cells that suppress autoreactive T cells and maintain immune self-tolerance. #physiology #immunology #immunity #nobelprize
🧬 Nobel Prize 2025 in Physiology or Medicine: Part 1 Penelitian oleh Prof. Shimon Sakaguchi yang pada tahun 2025 menerima Nobel Prize in Physiology or Medicine, membuka jalan bagi penemuan Regulatory T cells (Treg). Dalam studi klasiknya (J. Immunol., 1995), limfosit dari tikus BALB/c normal (nu/+) diisolasi dan dibagi menjadi lima kelompok: 1️⃣ Whole lymphocytes (semua sel) 2️⃣ CD25⁻ lymphocytes (semua sel, CD25⁺ dihilangkan) 3️⃣ CD4⁺ CD25⁻ (hanya T helper tanpa CD25) 4️⃣ CD4⁺ CD25⁺ (T helper dengan CD25) 5️⃣ CD8⁺ CD25⁻ (T sitotoksik tanpa CD25) Kelima fraksi ini ditransfer ke tikus BALB/c nu/nu (athymic) yang tidak memiliki timus. Hasil setelah ±3 minggu pengamatan menunjukkan: • Kelompok CD25⁻ dan CD4⁺ CD25⁻ mengalami autoimunitas multipel (gastritis, oophoritis, thyroiditis, glomerulonefritis). • Kelompok whole lymphocytes, CD4⁺ CD25⁺, dan CD8⁺ CD25⁻ tetap sehat. 🧩 Kesimpulan awal: sel CD4⁺ CD25⁺ berperan menekan aktivasi sel T autoreaktif dan menjaga toleransi The work of Shimon Sakaguchi, awarded the 2025 Nobel Prize in Physiology or Medicine, was pivotal in identifying Regulatory T cells (Treg). In his 1995 Journal of Immunology study, Sakaguchi isolated lymphocytes from normal BALB/c (nu/+) mice and divided them into five groups: 1️⃣ Whole lymphocytes – all cells untreated 2️⃣ CD25⁻ lymphocytes – all cells with CD25⁺ removed 3️⃣ CD4⁺CD25⁻ – helper T cells without CD25 4️⃣ CD4⁺CD25⁺ – helper T cells expressing CD25 5️⃣ CD8⁺CD25⁻ – cytotoxic T cells without CD25 Each group was transferred into BALB/c nu/nu (athymic) mice, which lack a thymus. After about 3 weeks, the results were striking: • CD25⁻ and CD4⁺CD25⁻ groups developed multiple autoimmune diseases (gastritis, oophoritis, thyroiditis). • CD4⁺CD25⁺, CD8⁺CD25⁻, and whole lymphocyte groups remained healthy. 🧩 Conclusion: CD4⁺CD25⁺ cells act as regulatory T cells that suppress autoreactive T cells and maintain immune self-tolerance. #physiology #immunology #immunity #nobelprize
Alex Pereira with the coldest celebration I have ever seen in my life 🥶 #UFC300 #UFC #MMA #AlexPereira #poatan #fight #ko #knockout
Alex Pereira with the coldest celebration I have ever seen in my life 🥶 #UFC300 #UFC #MMA #AlexPereira #poatan #fight #ko #knockout

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