@biolayne: Creatine Improves Symptoms of Depression? A new study investigated the effects of 8 weeks of cognitive behavioral therapy (CBT) with or without creatine supplementation on symptoms of depression (PMID: 39488067). 100 men & women (50 of each) were randomized to either a group doing CBT + creatine (5g creatine monohydrate per day) or CBT + placebo. After 8 weeks both treatments reduced symptoms of depression, but the group taking creatine had significantly better outcomes, by a pretty decent margin The researchers used a validated questionnaire called a PHQ-9 to measure depression severity. A score of equal to or more than 5 indicates depression. 5-9 is considered mild depression, 10-14 is moderate, 15-20 is moderate-severe, and equal to or more than 20 is considered severe depression. The average starting score was 17.6 & 17.8 for the placebo & creatine groups respectively (not statistically different). After 8 weeks the average score in the placebo group was 11.9. The average score in the creatine group was 5.8! 🤯 Now, this is just one 8 week study so we need to be cautious with how much weight we give to it. Still, this is in line with other research on creatine indicating various cognitive improvements with creatine (PMID: 39070254). Add to this the fact that creatine is very safe (PMID: 28615996) & relatively cheap. Not to mention it helps you build muscle & get stronger… what is not to like? (PMID: 37432300) Wow! Pretty wild huh? Now that said, I am NOT saying creatine should be a replacement for therapy or pharmaceutical help for depression. I am simply saying there is emerging evidence that this may be a low cost, safe way to help improve your brain & body health but don’t get suckered into other ‘improved’ forms of creatine. They are all scams as I have covered previously. Use tried & true Creatine Monohydrate. If you are interested in trying creatine monohydrate, check out my Recovery product from my supplement line @outworknutritionofficial at the link in my bio

Layne Norton, PhD
Layne Norton, PhD
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