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Tuesday 02 September 2025 10:44:25 GMT
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2025-09-02 21:13:39
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✅ Question-1) D) Digoxin Reason: Digoxin increases cardiac contractility by inhibiting Na⁺/K⁺-ATPase, improving calcium availability. It does NOT significantly increase heart rate—it may even slow it due to vagal stimulation. Dobutamine increases contractility but also increases heart rate, so it’s not the correct choice. ✅ Question-2) : B) Meperidine Reason: Most opioids (including morphine) cause miosis (pinpoint pupils). Meperidine is the exception: it causes mydriasis due to its anticholinergic properties. Therefore, only Meperidine causes dilation of pupils. ✅ Question-3) A) Buprenorphine Reason: Buprenorphine is a partial μ-opioid receptor agonist, producing limited opioid effect. Methadone is a full μ-agonist, used for opioid dependence maintenance. Thus, the partial agonist is Buprenorphine. ✅ Question-4) : A) Celecoxib Reason: Celecoxib is a selective COX-2 inhibitor, causing less gastric irritation and less platelet inhibition. Ketorolac is a non-selective NSAID with strong COX-1 inhibition. Therefore, only Celecoxib is COX-2 selective. ✅ Question-5) B) Oxcarbazepine Reason: Oxcarbazepine is more likely to cause hyponatremia due to SIADH-like effects. Carbamazepine also causes hyponatremia, but Oxcarbazepine has a higher risk. This makes option B the correct answer. ✅ Question-6) C) Heparin Reason: Unfractionated Heparin (UFH) requires aPTT monitoring because its effect is variable. Enoxaparin (LMWH) has predictable pharmacokinetics, so routine monitoring is not required. ✅ Question-7) A) Clarithromycin Reason: Clarithromycin causes less GI upset than Erythromycin because it has less motilin receptor stimulation. However, it has stronger CYP450 inhibition, increasing drug interactions. So Clarithromycin fits both criteria in the question. ✅ Question-8) Clonidine Reason: Clonidine is an α2-agonist that suppresses sympathetic outflow. Sudden withdrawal causes a rebound surge of catecholamines, leading to severe hypertension. Prazosin does NOT cause rebound hypertension when stopped. > Disclaimer: This video is for educational purposes only. It does not provide medical advice. Always consult a qualified healthcare professional for medical concerns. 🎙️ Voice narration generated with AI (Adam – ElevenLabs). #medusachallenge #Usa #nursingstudent #quiz #pharmacist
✅ Question-1) D) Digoxin Reason: Digoxin increases cardiac contractility by inhibiting Na⁺/K⁺-ATPase, improving calcium availability. It does NOT significantly increase heart rate—it may even slow it due to vagal stimulation. Dobutamine increases contractility but also increases heart rate, so it’s not the correct choice. ✅ Question-2) : B) Meperidine Reason: Most opioids (including morphine) cause miosis (pinpoint pupils). Meperidine is the exception: it causes mydriasis due to its anticholinergic properties. Therefore, only Meperidine causes dilation of pupils. ✅ Question-3) A) Buprenorphine Reason: Buprenorphine is a partial μ-opioid receptor agonist, producing limited opioid effect. Methadone is a full μ-agonist, used for opioid dependence maintenance. Thus, the partial agonist is Buprenorphine. ✅ Question-4) : A) Celecoxib Reason: Celecoxib is a selective COX-2 inhibitor, causing less gastric irritation and less platelet inhibition. Ketorolac is a non-selective NSAID with strong COX-1 inhibition. Therefore, only Celecoxib is COX-2 selective. ✅ Question-5) B) Oxcarbazepine Reason: Oxcarbazepine is more likely to cause hyponatremia due to SIADH-like effects. Carbamazepine also causes hyponatremia, but Oxcarbazepine has a higher risk. This makes option B the correct answer. ✅ Question-6) C) Heparin Reason: Unfractionated Heparin (UFH) requires aPTT monitoring because its effect is variable. Enoxaparin (LMWH) has predictable pharmacokinetics, so routine monitoring is not required. ✅ Question-7) A) Clarithromycin Reason: Clarithromycin causes less GI upset than Erythromycin because it has less motilin receptor stimulation. However, it has stronger CYP450 inhibition, increasing drug interactions. So Clarithromycin fits both criteria in the question. ✅ Question-8) Clonidine Reason: Clonidine is an α2-agonist that suppresses sympathetic outflow. Sudden withdrawal causes a rebound surge of catecholamines, leading to severe hypertension. Prazosin does NOT cause rebound hypertension when stopped. > Disclaimer: This video is for educational purposes only. It does not provide medical advice. Always consult a qualified healthcare professional for medical concerns. 🎙️ Voice narration generated with AI (Adam – ElevenLabs). #medusachallenge #Usa #nursingstudent #quiz #pharmacist
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